Hypersensitivity (PCA and DTH) Response in H. diminuta Infected Mice, Treated with Praziquantel and Ivermectin

The objective of this study was to investigate the immunomodulatory efficacy of drugs (Praziquantel and Ivermectin) in Hymenolepis diminuta infected mice. The drugs were administrated to the infected mice on 13 , 14 and 15 post infection days. The immunomodulation due to test drugs was observed th th th on PCA and DTH response. PCA and DTH reactions were found to be directly proportional to the dose of drugs. PCA response was maximum (23.4 mm) in praziquantel treated mice and minimum (20.2 mm) in ivermectin treated mice. DTH response was maximum (16.4 mm) in praziquantel treated mice and minimum (10.4mm) in ivermectin treated mice. Significant increase in PCA and DTH responses in the infected mice indicates stimulated cell mediated as well as humoral immunity. Obtained results indicate that both studied drugs can be good cestocidal agent and may boost the immune response of the host but Praziquantel is more effective immunomodulatory agent than Ivermectin.